A Robust Pipeline

Triple Negative Breast Cancer

Lung Cancer

Prostate Cancer

Colorectal Cancer

Gliobastoma

Pancreatic Cancer

And a Strong Patent Portfolio

No prior art discovered on central SRC-3-KO Treg cancer patent:

  • Covers all cancers
  • Covers any method of editing the cell

Treg Engineering Patent

The manufacturing of human regulator T regulatory cells by any method and for any cancer type. The process in which a patient’s own Treg cells are removed from the blood, modified, and given back.

Molecular Inhibitor Patent

Small molecule inhibitor blocks the transcriptional activity that also promotes its degradation in cancer cells. Inhibitor compound with dual effect: 1. Blocking growth of cancer cells. 2. Blocking Treg inhibition, promoting immune system response.

Small Molecule Enhancer Patent

Patent for the synthesis and use to stimulate target genes for the treatment of heart attack and stroke.

Future Applications

The same SRC-3 mechanism can be manipulated by small molecules to dramatically improve non-malignant diseases. In preclinical studies, tremendous promise has been shown in:

MI & Heart Failure

SRC-3 stimulator treatment after MI results In >55% reduction in scar volume allowing the heart to preserve function, plus:
❖ Decreased cell death
❖ Decreased inflammatory response
❖ Reparative macrophages
❖ Improved fibrotic remodeling
❖ Increased fibroblast NRF2
expression
❖ Decreased infarct size/progression
❖ Improved cardiac function

Stroke

SRC-3 stimulator treatment after stroke results in 65% improvement in stroke recovery, plus:
❖ Decreased apoptosis
❖ Decreased inflammatory response
❖ Reparative microglia
❖ Decreased scarring
❖ Increased astrocyte NRF2 expression
❖ Decreased infarct size/progression
❖ Improved neurologic function
❖ Increased Treg

Expanded Applications

These same mechanisms that alter gene regulation can be expected to have a similar effect on many non-malignant conditions.
❖ Diseases of fibrosis, eg, interstitial pulmonary fibrosis
❖ Diseases of aberrant wound healing
❖ Selected autoimmune disease
❖ Autoinflammatory diseases
❖ Hypertrophic scar